Knoxville is located in south-central Iowa, some 25 miles southeast of Des Moines. The area was originally inhabited by Native Americans of the Sac and Fox tribes. At that time, prairie grass covered the countryside at heights of 8 to 10 feet. In 1835, Dragoons first explored the Des Moines River valley through this area. In 1842, the Sac and Fox Indians signed a treaty to sell lands in central Iowa to the new settlers known as the New Purchase of 1842. By 1843, settlers began moving here. The first Marion County Courthouse was erected three years later.
Knoxville was founded in 1845 when Joseph Robinson and James Montgomery, Commissioners from Scott and Wapello County, selected the site for Knoxville and designated it as the county seat. They named Knoxville in honor of General Henry Knox, hero of the Revolutionary War. The City’s main streets are named after Robinson and Montgomery.