La Crosse was founded in 1876, was named after the city of La Crosse, Wisconsin. La Crosse subsequently became the intended county seat, and county records were transferred there from the temporary county seat, nearby Rush Center. A county seat war ensued between the two communities, lasting until La Crosse was declared the permanent county seat and the construction of the county courthouse in 1888.
In the 1960s, La Crosse became a regional center of barbed wire collecting, leading to the establishment of the Kansas Barbed Wire Museum and the nicknaming of the city as "The Barbed Wire Capital of the World"